mad-lab

Michael A. DeJesus

Senior Computational Biologist

Laboratory of Host-Pathogen Biology, The Rockefeller University

Transposon insertions along a stretch of genome. The empty stretch is an essential gene: disrupting it kills the cell, so no insertions survive there.

Software

TRANSIT

Statistical methods and graphical software for analyzing Himar1 transposon sequencing data.

Pebble

The Rock Laboratory's web portal for designing, analyzing, visualizing and sharing mycobacterial functional-genomics data.

Recent papers

  1. Comprehensive mapping of essential-gene interactions in M. tuberculosis

    Kresse, I.J.*, Sayegh, N.Y.*, Munsamy-Govender, V., Na, A., Nitz, S., Ozakman, Y., Bosch, B., Gonzalez, S., Poulton, N.C., Reddy, A., Wallach, J.B., Aguilera Olvera, R., Castro, A., Kim, H., Wong, A.I., Tornow, N., Bueler, S.A., Law, W.W.H., Glickman, M.S., Rubinstein, J.L., Schnappinger, D., DeJesus, M.A.†, Rock, J.M.†

    Nature (2026)

    *Co-first authors. †Co-senior authors.

  2. Utilization of a CRISPRi-based ex vivo challenge model to reveal temporally dependent gene essentiality in intracellular Mycobacterium tuberculosis

    Theriault, M.E., Wong, A.I., DeJesus, M.A., Pisu, D., Lee, B.N.R., Kirukubar, G., Li, S., Wallach, J.B., Schnappinger, D., Lê-Bury, G., Russell, D.G., Rock, J.M.

    mBio 17(5):e00610-26 (2026)

  3. Transcription attenuation amplifies collateral vulnerabilities in rifampicin-resistant Mycobacterium tuberculosis

    Eckartt, K.A., Munsamy-Govender, V., Quiñones-Garcia, S., DeJesus, M.A., Ju, X., Liu, S., Rock, J.M.

    Nature Microbiology 11(6):1696–1710 (2026)

All publications